Heat-shock Protein Synthesis in Animal Cells Induced by Gold Microheaters
نویسندگان
چکیده
In this work we describe a new way to investigate the effect of heating on the synthesis of heat-shock proteins (HSP) in mammalian cells by using gold microheaters in liquid chamber. We have successfully fabricated and thermally calibrated gold microheaters on which we could grow a monolayer of mammalian cells and heat-shock only a few of them by controlling temperature distribution over the device. Besides a better understanding of hyperthermia related biological processes, this work may open new routes to investigate the expression and the pathway of heat shock proteins.
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